Feb 20, 2017: Two new post-doctoral positions are now open. See below for more details on the positions and how to apply.
Feb 20, 2017: A post-doctoral position is available for a computational biologist to undertake research in the area of plant single cell genomics. The research will involve the analysis of large-scale transcriptomic and epigenomic datasets to investigate plant cell identity and dynamics, with a particular focus on sequencing-based single cell resolution analyses. Candidates with a background in computational biology/mathematics/statistics and experience in cell biology and advanced high-throughput genomics are encouraged to apply. Further information is available here, and applications are open online.
Feb 20, 2017: A post-doctoral position is available to lead the development of artificial transcriptional regulators and programmable genetic circuits in plants. The research will utilize molecular, genomic, and gene editing techniques to generate synthetic genetic circuits that integrate multiple signals to produce customizable transcriptional outputs. Candidates with a background in plant transcriptional regulation, genome editing, or synthetic biology are encouraged to apply. Further information is available here, and applications are open online.
Our research aims to understand how readout of the information encoded in the DNA of plant and animal genomes can be influenced by the epigenome, the extent to which epigenomic modifications such as DNA methylation can be altered by the environment and in disease states, and to develop molecular tools for precision epigenome engineering.
By modulating accessibility to the information encoded in the genome, chemical modifications of the DNA and associated proteins can affect gene activation and repression to execute distinct transcriptional programs and impart a stable state of transcriptional activity. We use advanced DNA sequencing, molecular, genetic and computational techniques to generate whole-genome high resolution maps of epigenetic modifications in a diverse range of complex multicellular organisms, including plants, humans, mice, and diverse vertebrates. Through these studies we aim to elucidate the mechanistic underpinnings of how the epigenome is established and dynamically modified, and how it affects the cellular readout of the underlying genetic information.
Developing a comprehensive understanding of how the cell utilizes the epigenome is essential in order to both understand the roles it plays in eukaryotic development and stress response, and to develop effective strategies to remedy its disruption in disease states.
Our research is generously supported by funding from the Australian Research Council, the National Health and Medical Research Council, the Raine Medical Research Foundation, The Sylvia and Charles Viertel Charitable Foundation, The University of Western Australia, and the Australian government.